As a young child, Takashi Natsume believed his ability to see youkai to be nothing but a curse. Now a high school student, Natsume has managed to heal from his old wounds and form unbreakable bonds with humans and youkai alike. Natsume's newfound friendships—including the one with his spirit bodyguard Madara, nicknamed "Nyanko-sensei"—are often interlaced with his duty to return the names of the spirits written inside the Book of Friends, his late grandmother Reiko's keepsake. While more remarkable youkai reach out to him, Natsume discovers that he still has much to learn about the world that surrounds him.
Tanuma gives Natsume some clay, and he tries his hand at sculpting a figure. However, the next day, the figure has disappeared, and other strange things are happening in the house. Is a Yōkai causing mischief in the house? Or is it just a rat?
Natsume is forced to help rebuild a tiny house that's a residence for a goddess.
Natsume is caught up in a mysterious game between youkai and man.
Natsume and Kitamoto are victims of a horrid curse.
Chobi is depressed because his favorite comb broke. Meanwhile, Natsume sees a white dragon in the sky...
Natsume meets Matoba in an unusual place. Matoba hunts for a dangerous yokai at an abandoned mansion.
Taki's brother suddenly comes home from college, and has something very important on his mind...
Nishimura finds Natsume coming to visit him each night at his house, but something seems strange...
Natsume finds himself in a house with a strange ritual, and unknown forces moving against those who would perform it.
Natsume, Natori and Matoba work to complete the ritual to welcome a powerful god.
Natsume meets the very first Yokai whose name was written in the Book of Friends.
Natsume takes in a strange origami doll that shows wonderful dreams.