The Muppets have a new show at the KMUP network and a new host, Clifford (no one else wanted the job). In need of a big star for the first episode, Clifford accidentally agrees to both Michelle Pfeiffer and Miss Piggy guest staring without them knowing.
Garth Brooks surprises everyone when he says he'll be doing something different for the show and won't sing any country music songs.
As the show goes on with Billy Crystal, new securtity guard Bobo the Bear keeps other guests from entering the station, including a jazz band for the show's last number.
John Goodman saves the lives of Miss Piggy's annoying nephews (Andy and Randy), but soon regrets it when they become his slaves and won't leave him alone.
Bobo falls in love with Cindy Crawford. As Bobo tries to express his feelings to her, Cupid is left in charge of security and one of his arrows accidentally makes Sal love Johnny.
Johnny seems thrilled when Tony Bennett guest stars, but he gets nervous about working with the famous singer and has difficulty performing.
The Muppets have even more pressure to make the show a success when a crazed individual known as the Mad Bomber threatens to blow up the studio if the ratings drop below fifty.
Old school friends, Gonzo and Jason Alexander, attempt to bring their musical onto the show. But their disagreements could end the project.
Miss Piggy is due to be in the show's closing number, but she is late for various reasons, which causes some panic for Clifford and the others.
A freak incident in the elevator leaves Martin Short in a tight squeeze and later some delicious spaghetti sauce leaves him feeling large.