Eek feels unappreciated and runs away from home. He winds up living with a sweet old lady, who nearly gets him killed when she takes him to the zoo rather than the vet.
Eek goes to the mall to get Wendy Elizabeth an autograph from her favorite TV stars, the Squishy Bearz. Unfortunately, Eek and the Squishy Bearz become fugitives after a rat gang dress up like the Bearz as part of a plot to ransom off the mayor's statue.
Eek falls in love with Annabelle, a 200 pound cat that just moved into the neighborhood. However, a deadly shark dog (Sharky) lives with her and won't let Eek anywhere near her. Eek will need some help from a nerdy, one winged Cupid, who will get his other wing if Eek kisses Annabelle.
Eek sneaks onto a space capsule to pursue an alien that abducted Annabelle.
Eek regrets saving a cute little pink bunny from a storm when he learns the bunny is really a large, tattooed psychopath. Worst of all, this bunny is planning to do away with the family.
Eek goes trick or treating with J.B. and Wendy Elizabeth, but eventually gets seperated. He then meets Cryptie, a ghost that got seperated from his family as well. While they try to find them, they are unknown their loved ones have fallen into the clutches of a beautiful and evil witch.
While on a trip to Uncle Vic's potato ranch with Mom and the kids, Eek finds himself mistaken for a secret agent by Sasha, a beautiful enemy spy falling in love with him. She leads him to the vengeful and disembodied villain, the Brain.
Annabelle falls in her swimming pool so Eek calls in the famous undersea explorer Jacques L'Duck to save her, but their underwater submersible is attacked by Sharky. Annabelle, Eek and Jacques are sucked down the plughole and emerge on a tropical island populated by natives who make Annabelle their queen. However, when they prepare to sacrifice her, Eek comes to her rescue.
Rock'n roll legend and cat food pitchman Melvis fakes his death, so his manager cons Eek into impersonating him.
Eek tells the neighborhood kittens an adventurous tale of when he was a kitten and helping a crew of pirates find treasure.
Wendy Elizabeth's geography grades need improving, so Mom takes the kids and Eek on a cross-country trip to learn about America. Eek, however, gets left behind at the first stop and has to run across the country to rejoin them.
Eek finds a package dropped from Santa's sleigh and makes sure to get it to it's destination, while spreading holiday cheer along the way.
Eek has a birthday present for Wendy Elizabeth: a Squishy Bearz inflatable termite farm. But the glass breaks and two spiders threaten the defenseless termites. The only one to escape, Termee, goes to Eek for help.