Three years have passed since Guido's death, and the time has come for Maria to start over, even sentimentally. Meanwhile Lele asks Bianca to take the plunge, but she discovers that she is still married to her ex-husband.
Bianca is determined to divorce in order to marry Lele, who in the meantime has met an old acquaintance of his, Virginia, in the context of research to cure a rare disease. In addition, problems ahead for Annuccia.
Bianca finds herself fighting on two fronts: seeking information about her ex-husband, and jealousy for Virginia, which grows despite Lele's reassurances. For Maria it's time for an attractive job offer.
Marco announces on the news that the mozzarella of Puglia d.o.p. di Nonna Enrica are produced with different milk and not with buffalo milk. Start the war!
Lele holds a lesson on the environment at Annuccia's school and is very popular among her daughter's classmates. In the meantime, Bianca's ex-husband, to put a spanner in her wheels, is determined to win over her little Inge with all the necessary little tricks.
A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and scared about the future, she finds herself weighing up her ex-husband Gus's offer. Meanwhile, grandmother Enrica plots to bring Maria and Marco closer.
The little ones of the Martini house are victims of bullying at school. When Lele and Bianca discover the situation, they convince the children to report what has happened to the teacher. Bobò will show all the necessary courage.
Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco unmask an illegal gambling den.
Maria, with the help of all her family, takes care of her little Palù and goes back to work in the clinic. Nonno Libero, having left for America, entrusts the task of running the company of Apulian food products to Nonna Enrica.
A hot air balloon ride offered by Gus turns into a cauldron of tensions. Lele joins them as soon as she can, just in time to see the engagement ring she gave Bianca fall down.
Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: in fact, she has taken a homeless person under her protective wing who leaves the whole family stunned.
The Martini Christmas dinner is, as always, a sea port. And this year, on the day when everyone is kinder, Lele will give Gus a break.
Lele, due to the presentation of the research for the drug he is working on, spends more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor.
Maria feels guilty for not having dedicated enough time to Marco lately. But when she shows up at her house by surprise, she'll be the one to be left speechless.
For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.
Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.
Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he would like to propose a TV format.
Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.
An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.
Between Maria and Marco everything goes swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce with Gus at a crucial moment in their relationship.
Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.
The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.
Like the rampant baron, Inge decides to run away from home, just on the day when Bianca is busy preparing a birthday cake for Maria. The searches begin.
The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.
At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.
The big day has arrived, and everyone is ready to reach Ovindoli where Lele and Bianca's wedding will take place. But as always in the Martini family, the unexpected is just around the corner. Will they make it?