As the second series kicks off, we learn Sean has moved to a new house in Chelsea, which he shares with a vicious pet dog, a couple of apathetic Bosnian refugee lodgers, and a spider claiming to be Elvis Presley. When Sean watches a scary movie, he becomes paranoid that a psycho killer is out to get him. The dead cast is soon resurrected, offering implausible explanations for their return, and Sean receives a package with tips for improving his ratings based on the popularity of The Golden Girls.
In order to pay his enormous phone bill, Sean gets a job in 'petroleum distribution' at the local garage. God rings to inform him that a man of the cloth is being sent round to knock some sense into him. Barry and Tony throw Sean a housewarming party.
While working at the garage, Sean meets Lizzie, a beautiful woman who shares his affinity for spontaneous choreographed song and dance numbers. He decides to propose marriage, but the moment is ruined when her father mysteriously explodes in Sean's back room.
The entire cast is under suspicion for the suspected murder of Bobby Workman, the man who did odd jobs around Sean's house. Sean is imprisoned for being Irish, but he doesn't mind, as it'll give him a chance to catch up on his reading. Led by Mrs Pebbles, the others must devise a plan to break him out of jail.
Sean has begun dating Trudy, a prison worker he met in last week's episode. Problems arise when Trudy announces she wants to have a baby, and it appears Sean doesn't get much say in the matter. Sean receives a further shock when he finds out his best friend Tony is already married with children.
Sean's attempt to throw a dinner party has ended in disaster, leaving Sean, Barry, and Tony in hospital and the women in their lives estranged. As they lie wounded and confused and struggle to piece together where exactly the evening wrong, the guys differ drastically in their recollection of events, but they agree on one point: they're ashamed to be men.
Tony spoils the story for the final episode, so a new plot must be devised at the last minute. When Sean's parents ring to tell him that he's adopted, he begins the search for his natural mother, encountering one candidate who looks suspiciously like Robert Smith of The Cure. Sean and Elvis the Spider perform a duet of I Got You Babe, and (of course) Sean receives a visit from a space alien.