Nate finds a Golden Retriever-Rottweiler mix to work with Kalani, an ex-marine with severe PTSD and anxiety; Laura works with Kelly, who suffers from a rare form of cerebral palsy, matching her with a Great Dane rescue.
Laura finds a Chihuahua mix for Isabella, a teenager suffering from depression, panic attacks and PTSD; Jesse, a Navy vet with limited mobility due to a spinal injury, works with Nate to rescue Rose, a Pitbull Mix.
Nate matches a German Shepherd rescue with Ed, a retired Air Force sergeant who suffers from a brain injury; Laura pairs a Jack Russell Terrier mix with Igor, who was born deaf.
Tommy, who has Diabetes, needs a Dog to detect his Blood Sugar levels; Nate starts training process with Shepherd Mix, while Laura works with Maxine, a Cancer Survivor who lost her Arm and needs a Dog to help around the House.
Nate finds a Lab Mix for Immanuel, who suffers from shaken baby syndrome and needs a Dog to support him during Seizures; Laura rescues a Poodle Mix for Carmel, a former Marine with PTSD and a serious back injury.
Nate rescues a Havanese for Diana, who lost part of her leg in a rock climbing accident. Laura works with Eric, who suffers from late-onset Tay-Sachs disease; she finds a Lab mix to be a friend and press his life alert pendant if needed.