The young vets are now 18 months into their careers. Trude Mostue, Emma Milne and Joe Inglis each have a difficult case to deal with in their surgeries. Joe is attempting to remove an abscess from Gizmo the snake, a tricky enough procedure, but then his patient stops breathing. Trude has to remove a lump, too, which is attached to Wilbur the Vietnamese pot-bellied pig. Unfortunately pigs don't do well under general anaesthetic so it's a nerve-racking operation. And Emma has to open up a German shepherd dog who seems to have a large, chewed-up lump of carpet wedged inside her.
A Siamese kitten presents Steve Leonard with the most unusual case of his career, and his younger brother Keith is also facing a challenge: he's been hired as the minder for the new stars of a TV soap - two temperamental goats.
Joe Inglis struggles to save a pet rabbit with a life-threatening abscess. Flu-stricken Hannah Pollard wants a double makeover for herself and her dog. Joe's fiancée Emma Milne makes plans for their wedding day. Trainee horse specialist Sam Robinson investigates an intriguing case of poisoning.
It's Trude Mostue's 30th birthday and she's planning a day out with her sister Lene, but first she must deal with a blind cat and a rabbit with sore eyes. Newlywed's Alison and Craig Beck are put to the test when their cat is taken ill - Alison diagnoses a thyroid problem and Craig agrees to operate.
Trude Mostue deals with a sick gerbil and it's distraught owner. Steve Leonard fights to save the life of a puppy with the deadly Parvo virus, while his brother Keith treats an injured pig.
Craig and Alison Beck leave Bristol having accepted new jobs with rival surgeries in King's Lynn, Norfolk, and Joe Inglis and his fiancée Emma Milne find the house of their dreams in Cheltenham, Gloucestershire. At work, Emma treats a homeless puppy, and Alison rescues a cat.
A bemused budgie and an ailing Alsatian keep Trude Mostue busy, while Sam Robinson and her colleagues wait for the surgery's grey mare to give birth.
As Fiona Green struggles to save the life of a Staffordshire bull terrier that's swallowed rat poison, Steve Leonard treats a sick iguana and admits he knows little about this type of reptile. Steve's brother Keith is bracing himself for an important meeting with his boss.
Alison Beck brushes up her surgical skills after a gun dog is run down by a car. Meanwhile Joe Inglis and Emma Milne set off on their stag and hen weekends.
Emma Milne and Joe Inglis's wedding day arrives and the reception party aboard a river boat goes on late into the night. But for Trude Mostue and Sam Robinson it is just another working day. Trude is having to operate on a hamster - a tricky task on such a small creature. Its seven-year-old owner has perfect faith in Trude's powers. Equally stressed is Sam, in Hull, who has to perform a difficult operation on a very valuable, but hoarse, horse.