Karen #7, a young lady, travels with her dogs Milo, Charlie, and Sophia. She becomes enraged when restaurants and establishments, such as Dada's Diner, The Plotagon Lobby, Library, and Café, refuse to let her carry either of the dogs, despite the fact that most people have health issues and are allergic to dogs, and the dogs' barking irritates them. Joseph, Lindsey, and the rest of the team are puzzled as to why she travels with her pets. Milo and Charlie transform into humans and leave Karen #7 a short while later, and Sophia transforms into a human shortly after them and also leaves Karen. After a while, Sophia starts to become Milo's girlfriend.
Richard is irritated by a Karen who follows him with her dog, and she subsequently does the same to Cameron.
Karen returns with a new dog named Charlie and attempts to enter restaurants and businesses, only to discover that she is obliged to let Charlie go.
Karen's dogs, Milo and Charlie, have transformed into humans and fled from her home, causing Karen distress.
Karen develops a crush on Frederick, and they begin dating soon after, making Frederick Karen's first boyfriend.
Today is Claude's 28th birthday, and the entire crew is arranging a buffet with 30 people at Green Curry Plotagon.
Karen recognizes Milo and Charlie in their human forms after two days of not seeing them, but they are unfamiliar to her.
Milo and Charlie, who were formerly dogs but have now developed into people and are older than Karen, are no longer her property, although she believes differently.
Karen's dog, Sophia, has ran away from Karen after drinking a juice that changed her into a person, and she subsequently becomes Milo's girlfriend since she finds him attractive.
Officer Smith begs Tariq to become a substitute teacher since he has taken a week off from being a police officer.