Dyke Central is an Oakland-based dramedy centered around 30-something butch roommates Alex and Gin. The first season sees Gin fluttering from woman to woman while Alex attempts to sustain her seemingly-stable relationship with girlfriend Jackie, in the face of new life options and the resurfacing of an old flame.
Alex and Gin scramble to find a new roommate to ensure that Jackie, Alex's girlfriend, doesn't move into Dyke Central; meanwhile, Bay Area newcomer Fabiana sets out to discover the real Oakland.
Alex, Gin, and new roommate Fabiana decide to have Game Night at Dyke Central, during which some hidden things are revealed.
Wanting to impress their respective love interests, Gin & Jackie sign up to join Alex and Fabi's workout group. Molly is oblivious to the cute out-of-towner fawning over her.
Alex & Jackie go on a double date with Fabi & Sol, while Gin uses food to seduce her new interest.
Fabi is upset that Alex forced her to lie to Jackie. Alex reconnects with her love of gardening. Jackie freaks out when Alex doesn't pick up her phone. Gin is encouraged to try online dating. Mario has a rough day.
Gin's first online date piques her interest. Bev and Molly's new relationship quickly gets intense. Fabi's life moves in new directions.
Alex has to deal with Fabi & Sol newly dating. Gin starts a fun new job, while Jackie tries to set Alex up with an interview. Zack tells Mario he can't be his therapist anymore.
No one can seem to shake the feeling that there's something between Fabi and Alex.
While Alex guiltily focuses all her attention on Jackie, Fabi has to face the reality of Alex's relationship duties - again. Oli moves to Oakland, Molly does something very difficult to appease Bev, and Gin prepares to find out what Jackie is scheming.
The crew comes together for Gin's birthday... but she's not the only one in for a surprise.